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Compared with stable states such as substrates, intermediates, or products, the enzyme has a significantly greater affinity for unstable transition states, thereby reducing the energy barrier during the reaction

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This is consistent with the heterogeneous expression of mGluR1 in patients with breast cancer

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For drugs that are highly susceptible to first-pass metabolism, such as nitroglycerin, lidocaine, and propranolol, only a small fraction of the oral dose may reach the systemic circulation unchanged