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doi: 10.1016/j.bbadis.2018.09.002

Due to the inability to effectively produce cytokines and exert antiviral activity when CD8 + T cells are exhausted during acute immune activity and are re-exposed to HBV, chronic replication of HBV and the occurrence of HCC may result [45]
Endotoxin triggers the expression of an inducible isoform of NO synthase and the formation of peroxynitrite in the rat aorta in vivo