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[DOI] [PubMed] [Google Scholar] 119.Shi J, Zhao Y, Wang K, Shi X, Wang Y, Huang H, et al

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Analogs with hydroxyl in place of amine, 44 and 45 , were much less potent than 7 (IC 50 = 0.01 M) in inhibiting the purified protease (IC 50 = 0.5 M and 0.6 M)

Importantly, we evaluate recent potential therapeutic targets and promising interventions, providing guidance for future targeted treatment therapies against human diseases

The study design and concept, as well as its ethical validity and performance, were based on the actual recommendations of the Bundesinstitut fr Arzneimittel und Medizinprodukte (BfArM) (German Federal Institute for Drugs and Medical Devices) and the Paul Ehrlich Institute, in accordance with German laws and the principles of the Declaration of Helsinki and of Good Clinical Practice