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Description
Evaluation of pharmacokinetics compared with immediate-release tofacitinib and impact of food

This could enable the treatment of hypoxic tumors, which represent a major challenge in anticancer drug development

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Hg and other neurotoxicants: additive effect

Our findings open avenues to identify cancer subtypes that hyperprogress in response to ICT by hijacking myeloid-affiliated pathways and thus allows for the development of effective combination therapies by targeting this mechanism of hyperprogression, and also support the emerging strategy of combining epigenetic modulators with ICT to prevent tumor-promoting epigenetic processes in cancers that are resistant to ICT 50 and possibly other therapies