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It was identified that as the degree of ferroptosis increased, the proportion of TUNEL-positive cells significantly increased, suggesting that ferroptosis promoted HK-2 cell death under a high concentration of CaOx (Fig

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Tumor cells can alter TME composition by reprogramming stromal cell states and extracellular matrix (ECM) architecture via juxtacrine/paracrine signaling, inflammatory factor release, exosome exchange, and nutrient competition [125, 126] (Fig