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For the timepoint study ( n = 50), male and female APOE-TR mice were euthanized at three different timepoint (10-, 25-, and 50-weeks) for three homozygous genotypes: APOE2-TR, APOE3-TR, and APOE4-TR (Supplementary Table S1)

We performed a narrative review to present the main features of MVP biology, from the genetics and embryology to the pathophysiological processes involved in the development of this condition, as they have been identified throughout the years, mostly on animal models

Chapter 3.24Guarana