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NLRP3 inflammasome activation contributes to the pathogenesis of rheumatoid arthritis

DNA damage, caused by free radicals (ROS that have not been buffered by anti-oxidants) and inadequate repair mechanisms, disrupts gene regulation, leading to cell death or senescence [23,24,25]

Additional animal studies have demonstrated that holy basil extracts can reduce liver enzyme elevations caused by carbon tetrachloride, heavy metals, and other hepatotoxins, likely via antioxidant mechanisms [1]

Yet, under normal circumstances, uptake of supplemental coenzyme Q 10 from peripheral tissues/organs is likely limited because coenzyme Q 10 is ubiquitously synthesized (105)
Barlow-Walden LR, Reiter RJ, Abe M, Pablos M, Menendez-Pelaez A, Chen LD, Poeggeler B