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Free Radic Res (2018) 52:144555

doi: 10.1016/j.jrras.2024.101004 78 HasaninM.ElbahnasawyM

In addition, carrier-free nanoparticles GEM-CXB NPs formed by the nano self-assembly of the dual drugs gemcitabine and celecoxib, exhibit dual clearance of MDSCs and tumor cells thereby significantly enhancing antitumor effects by inducing ICD and alleviating MDSC-induced immunosuppression through MDSCs clearance (134)

Additionally, the increase in local interstitial tissue temperature enhances lymphatic and blood flow, aiding the migration of T cells and APCs

Azuma H, Paulk N, Ranade A, Dorrell C, Al-Dhalimy M, Ellis E, Strom S, Kay MA, Finegold M, Grompe M (2007) Robust expansion of human hepatocytes in Fah-/-/Rag2-/-/Il2rg-/- mice