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As the importance of subcellular metabolite transporters in controlling tumor initiation is poorly understood, it would be interesting to determine whether overexpression or knockout of these transporters is involved in tumorigenesis, metastasis, and immune modulation

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CYH33, a PI3K inhibitor, exhibited a manageable safety profile and preliminary antitumor efficacy in patients with PI3KCA-mutant ovarian cancer (NCT03544905)

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The increased ROS level impacts the integrity of the RBC membrane, which impacts the red blood cell (RBC) function, leading to impaired hemostasis and thrombosis