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There is growing evidence, including findings obtained in experiments using heterochronic parabiosis in mice as a model system, that age-related changes in circulating anti-geronic factors importantly contribute to the regulation of vascular aging processes and the genesis of endothelial dysfunction and oxidative stress in a noncell autonomous manner [9]

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Then, once a week for four more weeks

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It was previously approved by the FDA for diagnostic evaluation and treatment of pediatric GH deficiency and is now widely used off-label in research and clinical settings to address adult-onset GH insufficiency and age-related hormonal decline
