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The study found that test subjects treated with melanotan I (either three injections at 3-week intervals, or two injections at 4-week intervals) experienced a decline in the number of inflammatory acne lesions on their faces

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Higgins JP, Green S: Cochran Handbook for Systematic Review of Interventions: Assessing Risk of Bias in Included Studies
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Fielding, R., Riede, L., Lugo, J