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The mPTP is a multi-protein complex that, when persistently open, causes mitochondrial swelling, potentially leading to rupture of the mitochondrial outer membrane

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Therefore, it can be speculated about its potential role in protecting BBB ( In addition, mind bomb-2 (MIB2) and ferroptosis inhibitor liproxstatin-1 may regulate iron death-related pathways and oxidative stress in the hippocampus, which in turn may repair perioperative BBB damage (Zhao et al., 2021

Preugschat F, Carter LH, Boros EE, Porter DJ, Stewart EL, Shewchuk LM

2.1.5 Endocrine pathways Gut microbiota interact with the endocrine system by influencing the secretion of various gut hormones, including glucagon-like peptide-1 (GLP-1) and peptide YY (PYY) (Zeng et al., 2024)