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however, resistance to oxaliplatin remains a significant clinical challenge in HCC treatment
found that high expression of KIF20A in CRC cells was associated with oxaliplatin resistance, and that resistance to oxaliplatin in CRC could be overcome by disrupting the KIF20A/NUAK1/PP1/GPX4 pathway (Yang C
Furthermore, addressing the challenges of patient heterogeneity, drug resistance, and adverse effects will be critical for the successful translation of ferroptosis-targeted therapies into clinical practice
