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J Comp Physiol B 2024:112

NF-B, nuclear factor kappa B

The same mechanical strain explanation may apply to neuro-orthopedic cases, as both Arnold Chiari malformation, tethered cord syndrome and syringomyelia are marked by traction on the brainstem, which may lead to chronic compression or distortion of neural and glial tissue in the brainstem or spinal cord

Am J Mens Health (2019) 13(2):1557988319846749

The rupture of cell membranes within the tissue results in the combination of polyphenol substrates with polyphenol peroxidases, initiating browning reactions