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Finally, while the number of clinical investigations involving probiotics for the treatment of cardiometabolic diseases is growing (6671), there remains a relative dearth of clinical investigations utilizing genetically engineered live biotherapeutic products (LBPs) as pharmacological agents (48, 49)

Contrary to the reported positive effects of p53 and ATM on the oxidative PPP, other reports suggest that p53 inhibits the PPP, as the loss of p53 increases NADPH production 45

Abbreviations SG stress granules, PDAC pancreatic ductal adenocarcinoma, ACLY ATP-citrate lyase, ADM acinar-to-ductal metaplasia, NSDHL NAD(P) Dependent Steroid Dehydrogenase-Like, EMT epithelial-mesenchymal transition, SLC25A1 solute carrier family 25 member 1, GLI1 glioma-associated oncogene homolog 1, NSCLC non-small cell lung cancer, ACSL3 Acyl-coenzyme A (CoA) synthetase long-chain family member 3, ACC acetyl-CoA carboxylase, PAAD pancreatic adenocarcinoma, LUAD lung adenocarcinoma, REDD1 regulated in development and DNA damage responses 1, HIF hypoxia-inducible factor, PPAR peroxisome proliferatorsactivated receptors, CD36 cluster of differentiation 36, FASN fatty acid synthase, CRC colorectal cancer, AMPK AMP-activated protein kinase, n-3PUFA long-chain n-3 polyunsaturated fatty acids, the first unsaturated bond in polyunsaturated fatty acids occurs at the third position of the methyl end of the carbon chain, ERK extracellular regulated protein kinases, TFCP2 transcription factor CP2, BMP4 Bone Morphogenetic Protein 4, WNT5B Wnt Family Member 5B, VEGFA Vascular endothelial growth factor A, BRCA breast cancer, mTORC1 mechanistic target of rapamycin complex 1, SREBP sterol regulatory element-binding proteins 1, SCD stearoyl- coenzyme A desaturase, IFNGR1 IFN receptor subunit 1 Sphingolipid synthesis is essential for cancer proliferation [81]