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Hameed MK, Sheikh ZA, Ahmed A, Najam A

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Insulin-like growth factor-I provokes functional antagonism and internalization of beta1-adrenergic receptors

Analysis of donor islets in the Human Pancreas Analysis Program (HPAP) has revealed altered expression of genes involved in insulin granule docking and exocytosis in donors with IGT and type 2 diabetes, including reduced expression of STX1A , VAMP2 and UNC13A , which are critical components of the vesicle fusion machinery [23]