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An Agilent ZORBAX Eclipse Plus C18 (2.1 mm 50 mm, 1.8 m) was used as an analytical column, and an Agilent ZORBAX StableBond-C8 (2.1 mm 5 mm, 1.8 m) (Agilent, Santa Clara, CA, USA) was used as a guard column

Besides the implication of the I Na(L) in LCAC-mediated arrhythmias, treatment with I Na(L) inhibitors lidocaine, ranolazine, or TTX prevents LV diastolic dysfunction in Langendorff rat hearts (Maruyama et al., 2000