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Some protocols use an extended break matching the cycle length (8 weeks on, 8 weeks off)

When a cell over-expresses NNMT, it does two costly things at once: it burns through methyl-donor capacity, and it diverts nicotinamide away from NAD+ regeneration into an inert metabolite (1-methylnicotinamide) that gets excreted

2007 Copper tripeptide complexes increase VEGF production while decreasing TGF-1 secretion by dermal fibroblasts

The delay in implementation was to ensure stakeholders had enough time to learn and adapt to this change, especially as it pertained to the education of athletes, their entourage, and medical personnel

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