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Other drugs such as venlafaxine, pregabalin, and carbamazepine have also been assessed, but their utility for the prevention of oxaliplatin-induced CIPN is still controversial (Table 6)

In particular, inhibitors of the key enzyme Glutaminase have been designed over the years (82) and their studies are at a more advanced stage, being Glutaminase a soluble protein, i.e., easier to handle also in vitro

Leaves are used as appetizer, stomachic, diuretic and hemostatic [35]

Meanwhile, GPX4 activator enhances the overall defense of cells against oxidative damage

Oxidative stress and lipid peroxidation products in cancer progression and therapy