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Description
10.1038/s41580-022-00547-x

68 NeymotinA.CalingasanN

10.1002/jmv.20388 J

Mechanistically, the risk is attributed to the pharmacokinetic impact of piperine, which inhibits CYP3A4 and disrupts glucuronidation, increasing systemic curcumin exposure by over 20-fold and potentially converting otherwise safe doses into hepatotoxic levels in susceptible individuals

Mounjaro and Zepbound are registered trademarks of Eli Lilly and Company
