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Retrieved 30 December 2016

The CD38 hydrolase activity is largely responsible for the conversion of NAD + to ADO within the hypoxic, acidic MM niche [25]

Early preclinical studies showed that daratumumab effectively induced ADCC in a dose-dependent manner [30] and recent studies with isatuximab suggest that ADCC may be a more dominant effector mechanism than originally thought [24, 31]

Evidence-based guidelines: MAGNIMS consensus guidelines on the use of MRI in multiple sclerosisestablishing disease prognosis and monitoring patients

Obesity (Silver Spring) 2011;19(1 ): 11020
