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Acknowledgments This work was supported in part by grants PUJ IDs 4509 and 4327 to GEB

The genotyping was performed using an enrichment-capture custom gene panel according to the manufacturers protocol using 50 ng of DNA

To this end, multiple studies reported matrix metalloprotease- and ADAM-dependent cleavage sites at Arg31-Leu32 and Pro52-Leu53 that were inhibited by O-glycosylation at Ser 37 /Ser 41 (Goth et al., 2017

The development of this technology significantly enhances our ability to rapidly and accurately generate epigenetic profiles of tumor samples

If we expressed levels over NAA, we found obvious differences among substructures, where the Glu/NAA ratio was almost double in the cerebellum and hippocampus against the cortex, and a similar trend was observed also for ratios of GABA/NAA and Gln/NAA