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As the plasmid WT-RhoA would also be geranylgeranylated and blocked by DGBP, we also expressed a mutated RhoA in which the CAAX motif 42 was replaced with one signaling farnesylation (CVLS)

Originally researched for neurodegenerative conditions, Tesofensine demonstrated a profound impact on body weight and fat mass during clinical trials

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Hyperlipoproteinemia, hypertension, diabetes, obesity, and tobacco smoking are the main risk factors for atherosclerosis and its thrombotic complications

10.1016/j.cger.2022.04.004 208
