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This is based on the fact that resident bacteria in the colon produce cobalamin, which regulates gene expression in gut Bacteroidetes
doi: 10.1007/s00216-006-0529-8
Goldstein AL, Hannappel E, Kleinman HK
Secretion of ghrelin from rat stomach ghrelin cells in response to local microinfusion of candidate messenger compounds: a microdialysis study
10.1016/s1744-1161(11)70049-7 [DOI] [Google Scholar] Li C., Lu C
