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This allows for reactions with a broad spectrum of both physiological metabolites (such as estrogen, prostaglandins, and leukotrienes) and xenobiotics (including acetaminophen, persistent organic pollutants, and toxic metals such as mercury, arsenic, and lead)

Alteration in iron metabolism during retinal degeneration in rd10 mouse

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Shikonin effectively blocked the IKK/IKK complex formation in vitro and in vivo via preventing the IKK-binding domain (NBD) of IKK from entering the hydrophobic pocket of IKK ( Figure 3 ), resulting the inhibition of proliferation, migration, and invasiveness [60]