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The mechanism by which CD38 mediated PD-1/PD-L1 blockade resistance likely includes perturbation of adenosine receptor signaling in tumor microenvironment leading to immune modulation (87)

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More studies are needed to fully explore which genes or proteins are affected by these methyltransferases

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Further, it has been posited that temporal and spatial discoordination between the dynamics in key cell types during the repair process leads to inefficient outcomes 2
