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The prior vaccine, Zostavax, was thought to lose its effectiveness after a few years

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In another study, MKR mice were crossed with mice overexpressing a fatty acid translocase, CD36, in skeletal muscle (115)

Liu also hypothesizes that one explanation for the high levels of efficacy is that the vaccines might be triggering a nonspecific inflammatory response to the mRNA that could be heightening its specific immune response, given that the modified nucleoside technique reduced inflammation but hasnt eliminated it completely