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Description
Several groups are more prone to a B12 deficiency and should proactively monitor both dietary intake and possible symptoms: Vegans and vegetarians: Since B12 is found naturally in animal products, plant-based eaters often struggle to get enough through diet alone

Effects are cumulative, not immediate

Thioredoxin and thioredoxin reductase: Current research with special reference to human disease
[DOI] [PubMed] [Google Scholar] Liberati 2009 Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gtzsche PC, Ioannidis JPA, et al

But at accelerated rates during caloric deficit states exceeding 20% below TDEE
