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Alternately, when GSSG levels are high and the GSH/GSSG balance is shifted, the copper-coordinating cysteines become oxidized and Atox1 is unable to bind copper (Hatori et al., 2012)

Here, we detected an increase in PGC-1 with 2 weeks of glutathione intake, along with an increase in mtDNA content, indicating the activation of mitochondrial biogenesis

Additionally, SLC25A51 silencing significantly reduced mitochondrial NAD + levels and increased protein acetylation [193], while inducing a redistribution of the NAD + pool into the nucleus and cytoplasm [195]