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SIRT1/3 and AMPK/PGC-1 to promote mitochondrial biogenesis and quality control

F344 rats treated with pipermethystine (10 mg/kg) for 2 weeks resulted in significant increase in hepatic glutathione, cytosolic superoxide dismutase (Cu/ZnSOD), tumor necrosis factor alpha mRNA expression, and cytochrome P450 (CYP) 2E1 and 1A2, suggesting that pipermethystine caused adaptation to oxidative stress and possible drug-drug interactions (10)

Panc-1 cells were human patient-derived pancreatic ductal adenocarcinoma (PDAC) cancer cell line (from ATCC) that carries both oncogenic KRAS and p53 mutations 33

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