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NAD+ Flux Regulation: Studies focus on its mechanism of blocking NNMT, which may otherwise drain methyl groups and Nicotinamide, theoretically boosting the available pool of NAD+

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Evidence has shown that NNMT expression in white adipose tissue (WAT) is high in obesity-prone mice and low in obesity-resistant mice [2325] and significantly correlates with the percent fat mass in diet-induced obese mice [26]

Currently, there are no effective treatments for this side effect, making it crucial to explore potential alternatives like MeCbl that may alleviate these painful symptoms

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