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Description
Pegloticase (Krystexxa) breaks down uric acid
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Both enzymes exhibit Michaelis-Menten type kinetics: k cat (H165N) = 0.021 0.001 s -1 , K M (H165N) = 164 13 mM, k cat (H165N, F279I) = 0.022 0.001 s -1 , K M (H165N, F279I) = 112 6 mM (mean S.D.)
The field needs further comparison investigations, especially on small sequence-driven changes in binding behavior and biological response
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