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S - p -bromobenzylglutathione (BBG), an analogue of GSH, is traditionally used inhibitor developed from in vitro assays 5,6

L'encapsulation liposomale permet de librer le glutathion sous forme de gouttelettes lipidiques, tandis que l'actylation modifie chimiquement la molcule pour une meilleure rsistance la digestion gastrique

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As a result, patients on long-term opioid therapy often experience more pain, even at the same or higher doses of opioids, necessitating further increases in dosage that perpetuate the cycle of hyperalgesia