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Jeck, J.A

For example, it has been reported that CD8 + T cells have facilitated tumor ferroptosis by releasing IFN-, which disrupts the cystine uptake by tumor cells, triggers lipid peroxidation accumulation, and ultimately results in ferroptotic tumor cell death ( + T cells are more sensitive to ferroptosis inducers RSL3 than B16 and MC38 cancer cells ( + T cells underwent lipid peroxidation in lipid laden TME and became dysfunctional (179), targeting lipid peroxidation to enhance cancer therapy must consider the complex nature of TME

163 Because the red blood cell has no other way of generating NADPH, it depends strongly on the activity of the prime enzyme of NADPH production: glucose-6-phosphate dehydrogenase (G6PD)

Biochimie 2014, 99, 162168

Leisegang M et al