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A randomized, placebo-controlled trial in 559 elderly individuals with low serum levels of folate and vitamin B 12 and at increased risk of fracture evaluated the combined supplementation of very high doses of folic acid (5 mg/day) and vitamin B 12 (1.5 mg/day)
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10.1016/j.ceca.2009.03.012
Blood samples were taken from the saphenous or cephalic vein at predose and at 0.083, 0.25, 0.5, 1, 2, 4, 8, and 24 h following administration
Jeon et al., 2012
