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Although the AU-rich binding protein tristerrolin (TTP) reduced the expression of PD-L1 through AU-rich elements in the PD-L1 mRNA 3UTR, the MEK signal downstream of KRAS phosphorylates and inhibits TTP, thus increasing the expression level of PD-L1 102

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Compared to traditional microarray techniques, RNA-Seq offers superior sensitivity, resolution, and the ability to simultaneously detect the expression levels of thousands of genes

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Methods Mol Biol (2013) 1053:2751