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The administration of flavonoids to diabetic animals boosts the antioxidant potential of -cells by increasing both enzymatic and non-enzymatic antioxidants, consequently limiting ROS generation and lipid peroxidation in -cells and protecting them against autophagy, apoptosis, or necroptosis (73, 74)

Many people are eager to see results quickly and skip the lower doses, but the microdosing and titration data shows that gradual escalation produces better long-term outcomes

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Because comprehensive controlled human safety data are not established, any conclusions about tolerability in people remain unconfirmed