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The patients ammonia levels decreased dramatically to 90 mol/l (153 g/dl) within 7 h of treatment, rebounded to 402 mol/l (685 g/dl) within 10 h, but remained 1,500 mol/l (2,555 g/dl), high-dose CKRT (maximal blood flow rate (Qb) 3050 ml/min

However, both the glucose-only administration and its co-administration with melatonin failed to alter plasma insulin levels after 20 and 60 min ( Figure 4C )

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