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However, mitochondrial dysfunction can lead to a buildup of ROS due to an imbalance in their production and degradation 4,5 Another major source of ROS is NADPH oxidase (Nox), a membrane-bound enzyme complex that produces superoxide by transferring an electron to oxygen from NADPH

IF induces sirtuin-1 (SIRT1) expression, which enhances mitochondrial biogenesis and promotes deacetylation of autophagy-related proteins, thus facilitating the removal of damaged mitochondria and misfolded proteins [67]

Function of phytochelatin synthase in catabolism of glutathione-conjugates

Glutathione IV therapy works at a deeper level