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Palinski W., Rosenfeld M
Upon activation, Class I PI3K converts PIP2 to PIP3, attracting AKT to the cell membrane
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treated TNBC cells with icariin, they find that the LC3 II/LC3 I ratio (an indicator of autophagic flux) and BECN1 (a marker of autophagosome formation) increased while p62 (an indicator of autophagic degradation) decreased, indicating the promoting of autophagy through the AMPK/mTOR/ULK1 pathway [176]
