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Most clinical studies have found that BPC 157s therapeutic effects are sustained with continued use

Patel RP, Somasundram PM, Smith LK, Sheppard KE, McArthur GA

Additionally, other studies have shown that SP1 can be activated at the transcriptional level through HIF-1 binding to its promoter under hypoxic conditions [64, 65]

Terpstra M, Vaughan TJ, Ugurbil K, Lim KO, Schulz SC, Gruetter R