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This comprehensive review discusses the host innate and acquired immune response involved in the pathogenesis of AOM, including information on viral-induced pathological changes in the nasopharynx and the middle ear in animal models

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The clinical study GeneBank was supported in part by P01 HL076491, P01 HL098055, R01 HL103931 and the Cleveland Clinic Foundation General Clinical Research Center of the Cleveland Clinic/Case Western Reserve University CTSA (1UL1RR024989)