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In clinical trials, most participants receiving lecanemab or donanemab transitioned from being amyloidpositive to being amyloidnegative after 18 months of treatment (called treatmentrelated amyloid clearance or TRAC)

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Rubiolo, C

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Future direction The evolution of GLP-1RAs is increasingly shifting toward oral formulations, aiming to enhance patient adherence by eliminating the need for injections and addressing the logistical complexities associated with traditional peptide therapies [72, 73]