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Regulatory Flexibility Act (RFA) The RFA requires agencies to analyze options for regulatory relief of small entities, if a rule has a significant impact on a substantial number of small entities

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Its based on studies of the benzyl alcohol's effectiveness over time after a vial has been repeatedly punctured

Although, no in vivo studies have been performed to verify kidney localization in PKD mice models, these nephron-segment-specific peptides present an opportunity for future prodrug, nanoparticle, and peptide targeting studies