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doi: 10.3389/fcell.2025.1622544 Received 03 May 2025 Accepted 11 June 2025 Published 30 June 2025 Volume 13 - 2025 Edited by Yangchun Xie, Second Xiangya Hospital, Central South University, China Reviewed by Matija Zelic, Sanofi Research and Development, United States Nik T

Jao, S.-C

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Besides their role in inflammation, these cytokines are detrimental to the processes of fertilization and embryo development: TNF- increases the free implants adhesions and their invasiveness through its effect on matrix metallo-proteinases (157) while TGF- hinders the local immune activity by inhibiting the natural killer cells which in turn impede the development of embryos (158)

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