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These may include lack of sleep, smoking, food intolerances, diets high in sugars and processed foods, excess alcohol intake, and hormone or immune imbalances
Otani N, Hoshiyama E, Ouchi M, Takekawa H, Suzuki K
doi: 10.1016/j.jhep.2014.03.031
Molecular mechanisms of morphine tolerance and dependence
Correcting deficiencies is critical, as a shortage of nutrients like folate has been linked to birth defects
