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In the absence of MPC activity, import of pyruvate into the mitochondria is greatly diminished, meaning that less acetyl-CoA can be produced by pyruvate dehydrogenase and therefore that TCA cycle flux is diminished (Gray et al., 2015

Hair color is regulated by molecules called melanin

The diagram shows that nuclear factor E2-related factor 2 (NRF2) hyperactivation is necessary for NSCLC cells to grow in 3-D spheroid conditions

527 In lupus-prone mice, CQ promotes the expansion of Treg populations and suppresses CNS inflammation under both prophylactic and therapeutic dosing regimens

14:246-252 [PubMed: 3211093] 23