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The metabolic syndrome is associated with elevated circulating C-reactive protein in healthy reference range, a systemic low-grade inflammatory state

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doi: 10.1517/14712598.2014.898060

This creates what researchers call a "placebo gap"without large-scale clinical trials comparing IV therapy to placebo treatments for hangovers specifically, it's hard to know exactly how much benefit comes from the treatment versus the expectation of relief

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