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Reuptake inhibitor of serotonin, noradrenaline, and dopamine Tesofensine increases monoaminergic transmission by inhibiting the neuronal uptake of serotonin, dopamine, and noradrenaline, thus causing appetite suppression

The physiological actions of thyroid hormones are produced predominantly by T 3, the majority of which (approximately 80%) is derived from T 4 by deiodination in peripheral tissues

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MRI and dual-energy X-ray absorptiometry (DEXA) scans confirmed marked reductions in white adipose tissue throughout the body