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(A) Fluorescently labeled PI+CAM and ROS (200m)
The accumulation of unfolded or misfolded proteins triggers endoplasmic reticulum stress, which exacerbates the imbalance of cellular redox, thereby intensifying ROS generation (20, 21)
Jitrapakdee, S., Vidal-Puig, A
Such assays require costly equipment, skilled personnel and strict validation
Chromatin status is driven by the activity and level of chromatin-modifying enzymes such as DNA methyltransferases (DNMT) and histone deacetylases (HDAC) (90) ( Figure 2 )
